Clinical trials for ataxia

Sporadic ataxia caused by stroke, vitamin deficiency, or drug exposure are very responsive to treatment with medication. Likewise, ataxia caused by alcoholism can be controlled, and the sufferer protected against additional damage, by discontinuing alcohol use.

When ataxia is related to other conditions, like stroke, then an appropriate course of long-term care including physical therapy can help patients manage ongoing symptoms and maximize their independence. There is no cure for ataxia, but sufferers can live a full life no matter when they are diagnosed.

The following list of clinical trials are the most up to date Ataxia clinical trials provided by clinicaltrials. Adaptive devices are a crucial part of helping ataxia patients manage symptoms successfully. Based on their needs, they may use a cane, crutches, walker, or wheelchair. Sometimes, they may feel more comfortable with one device or another.

No one wants to be left out of activities because of ataxia. However, it may be necessary to slow walking pace.

Avoid using stairs when possible. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. Try the modernized ClinicalTrials. Learn more about the modernization effort.

Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information. Search for terms. Save this study. Warning You have reached the maximum number of saved studies Trial in Adult Subjects With Spinocerebellar Ataxia The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.

Listing a study does not mean it has been evaluated by the U. Federal Government. Read our disclaimer for details. Results First Posted : August 14, Last Update Posted : April 20, Dramatic extension of tumor latency and correction of neurobehavioral phenotype in Atm-mutant mice with a nitroxide antioxidant.

Free Radic Biol Med. Epub Jul 4. Mitochondrial dysfunction in ataxia-telangiectasia. Epub Dec 5. Triheptanoin versus trioctanoin for long-chain fatty acid oxidation disorders: a double blinded, randomized controlled trial. J Inherit Metab Dis. Epub Sep 4. Roe CR, Brunengraber H. Anaplerotic treatment of long-chain fat oxidation disorders with triheptanoin: Review of 15 years Experience.

Mol Genet Metab. Epub Oct Roe CR, Mochel F. Anaplerotic diet therapy in inherited metabolic disease: therapeutic potential. A double-blind, placebo-controlled trial of triheptanoin in adult polyglucosan body disease and open-label, long-term outcome. Epub Nov 6. A randomized, controlled, double-blind, crossover trial of triheptanoin in alternating hemiplegia of childhood. Orphanet J Rare Dis.

Long-term follow-up in an open-label trial of triheptanoin in GLUT1 deficiency syndrome: a sustained dramatic effect.

J Neurol Neurosurg Psychiatry. Epub Apr 4. Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epilepsy. J Neurochem. Epub Dec 2. Neurochem Res. Epub Oct 3. Increased susceptibility of airway epithelial cells from ataxia-telangiectasia to S.

Sci Rep. Erratum in: Sci Rep. J Pediatr. Epub Feb 2. Inflammation and transcriptional responses of peripheral blood mononuclear cells in classic ataxia telangiectasia. PLoS One. Nutritional status of patients with ataxia-telangiectasia: A case for early and ongoing nutrition support and intervention. J Paediatr Child Health. Epub Feb 6. Epub Aug 8. A larger group of patients enrolled in Phase II studies typically volunteers. Dosage varies. Study participants are often randomly assigned to one treatment.

Sometimes, neither the investigator nor the patient is aware of which treatment is used blinding. To learn more about blinding and randomization: Explaining Randomization in Clinical Trials Phase III usually involves a large number of participants anywhere from thousands of volunteers.

Offered in a larger geographical area Typically, the most prolonged phase in a clinical trial; lasts up to several years. Side effects are monitored closely, and the treatment could be terminated if deemed necessary. Read Other Blogs.

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